abstract：BACKGROUND:After neoadjuvant chemoradiotherapy (nCRT) for esophageal cancer, high pathologically complete response (pCR) rates are being achieved especially in patients with squamous cell carcinoma (SCC). An active surveillance strategy has been proposed for SCC patients with clinically complete response (cCR) after nC...

journal_title：BMC cancer

authors： Zhang X,Eyck BM,Yang Y,Liu J,Chao YK,Hou MM,Hung TM,Pang Q,Yu ZT,Jiang H,Law S,Wong I,Lam KO,van der Wilk BJ,van der Gaast A,Spaander MCW,Valkema R,Lagarde SM,Wijnhoven BPL,van Lanschot JJB,Li Z

更新日期：2020-03-06 00:00:00

abstract：BACKGROUND:Alterations in peripheral blood lymphocytes in cervical cancer have been reported, although conflicting views exist. The present study investigated the distributions of lymphocyte subsets in tumor tissue and peripheral blood samples from cervical cancer patients and precancerous lesion patients, and evaluate...

journal_title：BMC cancer

authors： Wu Y,Ye S,Goswami S,Pei X,Xiang L,Zhang X,Yang H

更新日期：2020-03-04 00:00:00

abstract：BACKGROUND:Dabrafenib and trametinib combination therapy is approved for the treatment of patients with BRAF V600E positive tumors including melanoma and lung cancer. The effect of BRAF and MEK inhibitors on the immune system is not fully understood although a number of case reports indicate autoimmune side effects rel...

journal_title：BMC cancer

authors： Dimou A,Barron G,Merrick DT,Kolfenbach J,Doebele RC

更新日期：2020-03-04 00:00:00

abstract：BACKGROUND:It is not known what combination of bevacizumab and chemotherapy agents is the best therapeutic regimen. Comparative study results among the efficacies of bevacizumab plus chemotherapy remain controversial in patients with HER2-negative metastatic breast cancer. METHODS:We searched Pubmed, Embase, and Cochr...

journal_title：BMC cancer

authors： Sun Z,Lan X,Xu S,Li S,Xi Y

更新日期：2020-03-04 00:00:00

abstract：BACKGROUND:The objective of this systematic review and meta-analysis was to determine the prognostic value of total tumor-infiltrating lymphocytes (TILs) and subtypes of TILs (CD4+, CD8+, and FOXP3+) in triple-negative breast cancer (TNBC). METHODS:A systematic search of the MEDLINE, EMBASE, and Web of Science databas...

journal_title：BMC cancer

authors： Gao G,Wang Z,Qu X,Zhang Z

更新日期：2020-03-04 00:00:00

abstract：BACKGROUND:Although combination chemotherapy (CC) is generally recommended in recurrent or primary metastatic gastric cancer (RPMGC), the results of randomized trials are conflicting. METHODS:A retrospective review was conducted on 687 RPMGC patients who received palliative chemotherapy. We compared the overall surviv...

journal_title：BMC cancer

authors： Choi JH,Choi YW,Kang SY,Jeong GS,Lee HW,Jeong SH,Park JS,Ahn MS,Sheen SS

更新日期：2020-03-02 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is the second most common cause of cancer-related death in the world. N6-methyladenosine (m6A) RNA methylation is dynamically regulated by m6A RNA methylation modulators ("writer," "eraser," and "reader" proteins), which are associated with cancer occurrence and development. Th...

journal_title：BMC cancer

authors： Qu N,Qin S,Zhang X,Bo X,Liu Z,Tan C,Wen G,Jiang H

更新日期：2020-02-28 00:00:00

abstract：BACKGROUND:Alteration in gut microbiota has been recently linked with childhood leukemia and the use of chemotherapy. Whether the perturbed microbiota community is restored after disease remission and cessation of cancer treatment has not been evaluated. This study examines the chronological changes of gut microbiota i...

journal_title：BMC cancer

authors： Chua LL,Rajasuriar R,Lim YAL,Woo YL,Loke P,Ariffin H

更新日期：2020-02-24 00:00:00

abstract：BACKGROUND:MicroRNAs (miRNAs) are small non-coding RNAs involved in post-transcriptional gene expression regulation and have been described as key regulators of carcinogenesis. Aberrant miRNA expression has been frequently reported in sporadic breast cancers, but few studies have focused on profiling hereditary breast ...

journal_title：BMC cancer

authors： Pessôa-Pereira D,Evangelista AF,Causin RL,da Costa Vieira RA,Abrahão-Machado LF,Santana IVV,da Silva VD,de Souza KCB,de Oliveira-Silva RJ,Fernandes GC,Reis RM,Palmero EI,Marques MMC

更新日期：2020-02-22 00:00:00

abstract：BACKGROUND:Whether or not double J (DJ) stenting during transurethral resection of a bladder tumour (TURBT) harms patients with regard to possible metachronous upper urinary tract urothelial cancer (UUTUC) development remains controversial. This study evaluated the impact of DJ compared to nephrostomy placement during ...

journal_title：BMC cancer

authors： Hupe MC,Dormayer L,Ozimek T,Struck JP,Hennig MJP,Klee M,von Klot CAJ,Kuczyk MA,Merseburger AS,Kramer MW

更新日期：2020-02-21 00:00:00

abstract：BACKGROUND:Diffusion weighted magnetic resonance imaging (DW-MRI) holds great potential for monitoring treatment response in cancer patients shortly after initiation of radiotherapy. It is hypothesized that a decrease in cellular density of irradiated cancerous tissue will lead to an increase in quantitative apparent d...

journal_title：BMC cancer

authors： Fliedner FP,Engel TB,El-Ali HH,Hansen AE,Kjaer A

更新日期：2020-02-19 00:00:00

abstract：BACKGROUND:Colorectal cancer (CRC) is a heterogeneous disease with a complex biology and a wide number of altered genes such as BRAF, KRAS and PIK3CA. Advances with new-targeted therapies have been achieved and available treating options have prolonged patient's survival. However, BRAF-mutated CRC patients remain unres...

journal_title：BMC cancer

authors： Miele E,Abballe L,Spinelli GP,Besharat ZM,Catanzaro G,Chiacchiarini M,Vacca A,Po A,Capalbo C,Ferretti E

更新日期：2020-02-17 00:00:00

abstract：BACKGROUND:Melanoma can be lethal if not detected early and treated. Early detection can be facilitated via skin self-examination (SSE) and as such, SSE is part of melanoma follow-up care for individuals with a prior history, who face a life-long risk of reoccurrence. The objective of the current study was to identify ...

journal_title：BMC cancer

authors： Coroiu A,Moran C,Bergeron C,Drapeau M,Wang B,Kezouh A,Ernst J,Batist G,Körner A

更新日期：2020-02-14 00:00:00

abstract：BACKGROUND:Increasing studies have demonstrated that long non-coding RNAs (lncRNAs) play an important role in tumor progression. However, the potential biological functions and clinical importance of Linc01234 in oral squamous cell carcinoma (OSCC) remain unclear. METHODS:We evaluated the expression profile and progno...

journal_title：BMC cancer

authors： Liu D,Jian X,Xu P,Zhu R,Wang Y

更新日期：2020-02-10 00:00:00

abstract：BACKGROUND:Pembrolizumab is effective as first-line therapy against advanced non-small cell lung cancer (NSCLC) in patients with programmed death ligand-1 (PD-L1) expression levels ≥50% [1]. However, it is not effective in all patients, and the factors predicting responses among this population remain unknown. METHODS...

journal_title：BMC cancer

authors： Morita M,Tamiya M,Fujimoto D,Tamiya A,Suzuki H,Hirano K,Fukuda Y,Yokoyama T,Kominami R,Kanazu M,Uchida J,Hara S,Yamashita S,Tomioka H

更新日期：2020-02-03 00:00:00

abstract：BACKGROUND:This planning study compares different radiotherapy techniques for patients with pituitary adenoma, including flatness filter free mode (FFF), concerning plan quality and secondary malignancies for potentially young patients. The flatness filter has been described as main source of photon scatter. MATERIAL ...

journal_title：BMC cancer

authors： Treutwein M,Steger F,Loeschel R,Koelbl O,Dobler B

更新日期：2020-02-03 00:00:00

abstract：BACKGROUND:Lymphovascular invasion (LVI) is a vital risk factor for prognosis across cancers. We aimed to develop a scoring system for stratifying LVI risk in patients with breast cancer. METHODS:A total of 301 consecutive patients (mean age, 49.8 ± 11.0 years; range, 29-86 years) with breast cancer confirmed by patho...

journal_title：BMC cancer

authors： Ni-Jia-Ti MY,Ai-Hai-Ti DL,Huo-Jia AS,Wu-Mai-Er PL,A-Bu-Li-Zi AB,Shi Y,Rou-Zi NE,Su WJ,Dai GZ,Da-Mo-la MH

更新日期：2020-02-03 00:00:00

abstract：BACKGROUND:The purpose of the present study was to obtain information on the use of PD-1/PD-L1 inhibitors by oncologists in China through a national questionnaire survey. METHODS:Between the 7th and 25th of July in 2019, a questionnaire designed by the Chinese Society of Clinical Oncology Immuno-Oncology (CSCO IO) Com...

journal_title：BMC cancer

authors： Zhang B,Song Y,Fu Y,Zhu B,Wang B,Wang J

更新日期：2020-01-31 00:00:00

abstract：BACKGROUND:Cervical cancer is the most common cancer and the leading cause of cancer death among women in Tanzania. Knowledge of and willingness to receive a cervical cancer screening are important determinants of prevention. This study aimed to describe women's awareness of cervical cancer and to explore the attitudes...

journal_title：BMC cancer

authors： Weng Q,Jiang J,Haji FM,Nondo LH,Zhou H

更新日期：2020-01-28 00:00:00

abstract：BACKGROUND:This study aimed to evaluate the safety and feasibility of self-expanding metallic stent (SEMS) followed by neoadjuvant chemotherapy prior to elective surgery for obstructing left-sided colon cancer. METHODS:Eleven consecutive patients with obstructing left-sided colon cancer between May 2014 and November 2...

journal_title：BMC cancer

authors： Han JG,Wang ZJ,Zeng WG,Wang YB,Wei GH,Zhai ZW,Zhao BC,Yi BQ

更新日期：2020-01-28 00:00:00

abstract：BACKGROUND:Lung adenocarcinoma (LUAD) is one of the most common cancer types, threatening the human health around the world. However, the high heterogeneity and complexity of LUAD limit the benefits of targeted therapies. This study aimed to identify the key prognosis impacting genes and relevant subtypes for LUAD. ME...

journal_title：BMC cancer

authors： Lv Z,Lei T

更新日期：2020-01-27 00:00:00

abstract：:Following publication of the original article [1], the authors reported an error in Fig. 6c and in the figure legends for Fig. 5c and Fig. 6c. ...

journal_title：BMC cancer

authors： Nilsson G,Kannius-Janson M

更新日期：2020-01-23 00:00:00

abstract：BACKGROUND:Preoperative chemoradiotherapy is the recommended standard of care for patients with local advanced rectal cancer. However, it remains unclear, whether a prolonged time interval to surgery results in an increased perioperative morbidity, reduced TME quality or better pathological response. Aim of this study ...

journal_title：BMC cancer

authors： Lichthardt S,Wagner J,Löb S,Matthes N,Kastner C,Anger F,Germer CT,Wiegering A

更新日期：2020-01-20 00:00:00

abstract：BACKGROUD:Pancreatic cancer is a highly malignant tumor of the digestive system. This secretome of pancreatic cancer is key to its progression and metastasis. But different methods of protein extraction affect the final results. In other words, the real secretion of proteins in cancer cells has been changed. Based on m...

journal_title：BMC cancer

authors： Liu P,Kong L,Liang K,Wu Y,Jin H,Song B,Tan X

更新日期：2020-01-20 00:00:00

abstract：BACKGROUND:This study aimed to explore the heterogeneity of circRNA expression pattern via microarray, and further evaluate the potential of 10 specific circRNAs as diagnostic and prognostic biomarkers in multiple myeloma (MM). METHODS:In exploration stage (stage I), circRNA expression profiles were detected by the mi...

journal_title：BMC cancer

authors： Zhou F,Wang D,Wei W,Chen H,Shi H,Zhou N,Wu L,Peng R

更新日期：2020-01-16 00:00:00

abstract：BACKGROUND:To evaluate radiomics analysis in neuro-oncologic studies according to a radiomics quality score (RQS) system to find room for improvement in clinical use. METHODS:Pubmed and Embase were searched up the terms radiomics or radiogenomics and gliomas or glioblastomas until February 2019. From 189 articles, 51 ...

journal_title：BMC cancer

authors： Park JE,Kim HS,Kim D,Park SY,Kim JY,Cho SJ,Kim JH

更新日期：2020-01-10 00:00:00

abstract：BACKGROUND:High grade gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN) with a Ki67 proliferation index > 20%, include well-differentiated tumours grade 3 (NET G3) and poorly differentiated (PD) neuroendocrine carcinomas (NEC). Abnormal p53-expression is a feature of PD tumours, while expression of chromogran...

journal_title：BMC cancer

authors： Nielsen K,Binderup T,Langer SW,Kjaer A,Knigge P,Grøndahl V,Melchior L,Federspiel B,Knigge U

更新日期：2020-01-10 00:00:00

abstract：BACKGROUND:To the best of our knowledge, no study has reported mediastinal shift accompanied with obstructive atelectasis due to bulky primary esophageal tumor components treated with adaptive radiotherapy and concurrent chemotherapy. CASE PRESENTATION:Here we report the case of a 65-year-old male patient diagnosed wi...

journal_title：BMC cancer

authors： Sakanaka K,Fujii K,Mizowaki T

更新日期：2020-01-06 00:00:00

abstract：BACKGROUND:Primary angiosarcomas of the right atrium are extremely rare, often resulted in missed diagnosis or misdiagnosis with routine examination tools. These malignant cardiac tumors are highly aggressive with generally poor prognosis. Surgical excision is the mainstay of treatment as it is essentially not responsi...

journal_title：BMC cancer

authors： Yu Y,Wang Q,Sun J,Zhao J,Chen S,Li Y

更新日期：2020-01-06 00:00:00

abstract：BACKGROUND:Cell migration and invasion are essential processes for metastatic dissemination of cancer cells. Significant progress has been made in developing new therapies against oncogenic signaling to eliminate cancer cells and shrink tumors. However, inherent heterogeneity and treatment-induced adaptation to drugs c...

journal_title：BMC cancer

authors： Shahi Thakuri P,Gupta M,Singh S,Joshi R,Glasgow E,Lekan A,Agarwal S,Luker GD,Tavana H

更新日期：2020-01-02 00:00:00

abstract：BACKGROUND:Breast cancer risk, development, and treatment are influenced by genetic variation in certain genes, namely those involved in cell proliferation, tumor suppression, and drug metabolism. In turn, the relevance of the aforementioned genetic variation to cancer depends on the ethnic group in question, highlight...

journal_title：BMC cancer

authors： Al-Eitan LN,Rababa'h DM,Alghamdi MA,Khasawneh RH

更新日期：2019-12-30 00:00:00

abstract：BACKGROUND:The principle of loss of iodine uptake and increased glucose metabolism according to dedifferentiation of thyroid cancer is clinically assessed by imaging. Though these biological properties are widely applied to appropriate iodine therapy, the understanding of the genomic background of this principle is sti...

journal_title：BMC cancer

authors： Suh HY,Choi H,Paeng JC,Cheon GJ,Chung JK,Kang KW

更新日期：2019-12-30 00:00:00

abstract：BACKGROUND:SPINK4 is known as a gastrointestinal peptide in the gastrointestinal tract and is abundantly expressed in human goblet cells. The clinical significance of SPINK4 in colorectal cancer (CRC) is largely unknown. METHODS:We retrieved the expression data of 1168 CRC patients from 3 Gene Expression Omnibus (GEO)...

journal_title：BMC cancer

authors： Wang X,Yu Q,Ghareeb WM,Zhang Y,Lu X,Huang Y,Huang S,Sun Y,Lin J,Liu J,Chi P

更新日期：2019-12-30 00:00:00

abstract：:Following publication of the original article [1], the authors reported that during the production process, Table 1 was omitted. ...

journal_title：BMC cancer

authors： Boon SS,Chen Z,Li J,Lee KYC,Cai L,Zhong R,Chan PKS

更新日期：2019-12-29 00:00:00

abstract：:Following publication of the original article [1], the authors reported an error in Figure 2, where the color code of the text boxes is reversed. Figure 2-amended shows the correct color association between the text boxes and the different areas in the map: Navarra, neighbouring communities and other Spanish communiti...

journal_title：BMC cancer

authors： de Sabando AR,Lafuente EU,García-Amigot F,Sánchez AA,Garofalo LM,Moreno S,Ardanaz E,Ramos-Arroyo MA

更新日期：2019-12-17 00:00:00

abstract：BACKGROUND:Retrospective studies show improved outcomes in colorectal cancer patients if taking statins, including overall survival, pathological response of rectal cancer to preoperative chemoradiotherapy (pCRT), and reduced acute and late toxicities of pelvic radiation. Major tumour regression following pCRT has stro...

journal_title：BMC cancer

authors： Jameson MB,Gormly K,Espinoza D,Hague W,Asghari G,Jeffery GM,Price TJ,Karapetis CS,Arendse M,Armstrong J,Childs J,Frizelle FA,Ngan S,Stevenson A,Oostendorp M,Ackland SP

更新日期：2019-12-17 00:00:00

abstract：BACKGROUND:Little is known about the relationship between the metabolite profile of plasma from pre-operative prostate cancer (PCa) patients and the risk of PCa progression. In this study we investigated the association between pre-operative plasma metabolites and risk of biochemical-, local- and metastatic-recurrence,...

journal_title：BMC cancer

authors： Zoni E,Minoli M,Bovet C,Wehrhan A,Piscuoglio S,Ng CKY,Gray PC,Spahn M,Thalmann GN,Kruithof-de Julio M

更新日期：2019-12-16 00:00:00

abstract：BACKGROUND:NF1(Neurofibromatosis type 1) is an autosomal dominant genetic disorder. Patients with NF1 have an increased risk of developing benign or malignant tumours, such as gastrointestinal stromal tumours (GISTs). However, the coexistence of NF1, GIST and colon cancer is very rare, and few cases have been reported ...

journal_title：BMC cancer

authors： Shang L,Fang Z,Liu J,Du F,Jing H,Xu Y,Dong K,Zhang X,Wu H,Jing C,Li L

更新日期：2019-12-05 00:00:00

abstract：BACKGROUND:Currently, clinical studies on the prognosis of prostate cancer (PC) taking aspirin were developing, but the precise mechanism of aspirin on tumor cells was still unclear. In addition, the conclusion that aspirin can improve the prognosis of PC patients continues to be controversial. Therefore, we collected ...

journal_title：BMC cancer

authors： Zhou J,Xia S,Li T,Liu R

更新日期：2019-12-05 00:00:00

abstract：BACKGROUND:The metabolic consequences of preoperative carbohydrate load in breast cancer patients are not known. The present explorative study investigated the systemic and tumor metabolic changes after preoperative per-oral carbohydrate load and their influence on tumor characteristics and survival. METHODS:The study...

journal_title：BMC cancer

authors： Lende TH,Austdal M,Bathen TF,Varhaugvik AE,Skaland I,Gudlaugsson E,Egeland NG,Lunde S,Akslen LA,Jonsdottir K,Janssen EAM,Søiland H,Baak JPA

更新日期：2019-12-04 00:00:00